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Researchers

Phillip Popovich


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-8576

Email: popovich.2@osu.edu

 

Current OSU Appointments

Professor, SBS-Neuroscience

Professor, Neurological Surgery

 

Degrees

1992 M.S., The Ohio State University

1995 Ph.D., The Ohio State University

 

Editorial Activities

present Journal of Neurodegeneration and Regeneration
present BMC Neurology
present Inflammation & Allergy - Drug Targets
present Experimental Neurology
present Neuroimmune Pharmacology
 

Honors

1993 - 1995 NINDS Neural Development, Plasticity, and Regeneration Training Grant.
1995 - 1997 Special Medical Research Fellowship. The Sandoz Corporation.
1997 Michael E. Goldberger Award for Research in Neural Regeneration and Functional Recovery.
2000 Invited Speaker NINDS Workshop – “Safety of Electrical Stimulation in the CNS�.
2000 Invited Speaker NIH Workshop – “Role of the Immune System in Spinal Cord Injuries�.
2003 Excellence in Teaching Award.
2004 Member. Neuroplasticity and Neurotransmitters (CNNT) Study Section, NIH-NINDS.
2006 Ray W. Poppleton Research Chair.
2006 - 2007 Vice President.
 

Journal Articles

POPOVICH, P.G., Streit, W.J., Stokes, B.T. "Differential expression of MHC class II antigen in the contused rat spinal cord." J. Neurotrauma. Vol. 10(1), (January 1993.): 37-46.

2. POPOVICH, P.G., Reinhard, J.F., Jr., Flanagan, E.M., Stokes, B.T. "Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma." Brain Res. Vol. 633, (January 1994.): 348-352.

Colachis, S.C., POPOVICH, P.G., Stokes, B.T. "Gallium nitrate and spinal cord injury: A pilot study of efficacy using an experimental model." Paraplegia. Vol. 32, (January 1994.): 86-92.

Semple-Rowland, S.L., Mahatme, A., POPOVICH, P.G., Green, D.A., Hassler, G., Jr., Stokes, B.T., Streit, W.J. "Analysis of TGF-?1 gene expression in contused rat spinal cord using quantitative RT-PCR." J.Neurotrauma. Vol. 12(6), (January 1995.): 1003-1014.

Horner, P.J., POPOVICH, P.G., Mullin, B.B., Stokes, B.T. "A quantitative spatial analysis of the blood-spinal cord barrier: II. Permeability after intraspinal fetal transplantation." Exp. Neurol.. Vol. 142, (January 1996.): 226-243.

POPOVICH, P.G., Stokes, B.T., Whitacre, C.C. "The concept of autoimmunity following spinal cord injury: possible roles for T-Lymphocytes in the traumatized CNS." J. Neurosci. Res. Vol. 45, (January 1996.): 349-363.

POPOVICH, P.G., Horner, P.J., Mullin, B.B., Stokes, B.T. "A quantitative spatial analysis of the blood-spinal cord barrier: I. Permeability after spinal contusion injury." Exp. Neurol.. Vol. 142, (January 1996.): 258-275.

POPOVICH, P.G., Wei, P., Stokes, B.T. "The cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats.." J. Comp. Neurol.. Vol. 377(3), (January 1997.): 443-464.

POPOVICH, P.G., Yu, J.Y., Whitacre, C.C. "Spinal cord neuropathology in rat experimental autoimmune encephalomyelitis: modulation by oral administration of myelin basic protein." J. Neuropathol. Exp. Neurol. Vol. 56(12), (January 1997.): 1323-1338.

POPOVICH, P.G., Whitacre, C.C, Stokes, B.T. "Is spinal cord injury an autoimmune disorder?." The Neuroscientist. Vol. 4(2), (January 1998.): 71-76.

Streit, W.J., Semple-Rowland, S.L., Hurley, S.D., Miller, R. C., POPOVICH, P.G., Stokes, B.T. "Cytokine mRNA transcription profiles in contused spinal cord and axotomized facial nucleus suggest a pro-regenerative role for inflammation and gliosis." Exp. Neurol.. Vol. 152(1), (January 1998.): 74-87.

POPOVICH, P.G., Guan, Z., Wei, P., Yu, J.Y., Huitinga, I., van Rooijen, N., Stokes, B.T. "Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury." Exp. Neurol.. Vol. 158(2), (January 1999.): 351-365.

Jakeman, LB, Guan, Z., Wei, P., Ponnappan, R., Dzwonczyk, R., POPOVICH, P.G., Stokes B.T. "Traumatic spinal cord injury produced by controlled contusion in mouse." J. Neurotrauma. Vol. 17(4), (January 2000.): 299-319.

McTigue, D.M., POPOVICH, P.G., Morgan, T.E., Stokes, B.T. "Localization of TGF-?1 and receptor mRNA after experimental spinal cord injury." Exp. Neurol.. Vol. 163, (January 2000.): 220-230.

POPOVICH, P.G., Stuckman, S., Gienapp, I.E., Whitacre, C.C. "Alterations in leukocyte phenotype and function following experimental spinal cord injury." J. Neurotrauma. Vol. 18(9), (January 2001.): 957-966.

POPOVICH, P.G. and Hickey, W.F. "Bone-marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord." J. Neuropathol. Exp. Neurol.. Vol. 60(7), (January 2001.): 676-685.

Jones, T.B., Basso, D.M., Sodhi, A., Pan, J.Z., Hart, Hart, R.P., MacCallum, R.C., Lee, S., Whitacre, C.C., POPOVICH, P.G. "Pathological central nervous system autoimmune disease is triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy." J. Neuroscience. Vol. 22, (January 2002.): 2690-2700.

Hayes, K.C., Hull, T.C.L., Delaney, G.A., Potter, P.J., Sequeira, K.A.J., Campbell, K., POPOVICH, P.G. "Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury." J. Neurotrauma. Vol. 19(6), (January 2002.): 753-761.

Jones, T Bucky; Basso, D Michele; Sodhi, Ajeet; Pan, Jonathan, Z; Hart, Ronald, P; MacCallum, Robert, C; Lee, Sunhee; Whitacre, Caroline, C; Popovich, Phillip G. "Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy.." The Journal of neuroscience : the official journal of the Society for Neuroscience. Vol. 22, no. 7. (January 2002.): -.

POPOVICH, P.G., Guan, Z., McGaughy, V., Fisher, L., Hickey, W.F., Basso, D.M. "The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation.." J. Neuropathol Exp. Neurol.. Vol. 61(7), (January 2002.): 623-633.

Popovich, Phillip, G; van Rooijen, Nico; Hickey, William, F; Preidis, Geoff; McGaughy, Violeta. "Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury.." Experimental neurology. Vol. 182, no. 2. (January 2003.): -.

POPOVICH, P.G. and Jones, T.B. "Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics.." Trends Pharmacol. Sci.. Vol. 24(1), (January 2003.): 13-17.

Sroga, J.M., Jones, T.B., McGaughy, V., POPOVICH, P.G. "Rats and mice exhibit distinct inflammatory responses after spinal cord injury.." J. Comp. Neurol.. Vol. 462(2), (January 2003.): 223-240.

P.G. POPOVICH, van Rooijen, N., Hickey, W.F., Preidis, G., McGaughy, V. "Hematogenous macrophages express CD8 and distribute to regions of cavitating pathology after spinal cord injury.." Exp. Neurol.. Vol. 182, (January 2003.): 275-287.

Jones, T Bucky; Ankeny, Daniel, P; Guan, Zhen; McGaughy, Violeta; Fisher, Lesley, C; Basso, D Michele; Popovich, Phillip G. "Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats.." The Journal of neuroscience : the official journal of the Society for Neuroscience. Vol. 24, no. 15. (January 2004.): -.

Jones, T.B., McDaniel, E.E., POPOVICH, P.G. "Inflammatory-mediated injury and repair in the traumatically injured spinal cord.." Current Pharmaceutical Design. Vol. 11(10), (January 2005.): 1223-1236.

Jones, T.B., Hart, R.P., POPOVICH, P.G. "Molecular control of physiological and pathological T-cell recruitment to the injured mouse spinal cord.." J. Neurosci.. Vol. 25(28), (January 2005.): 6576-6583.

Kigerl, Kristina; Popovich, Phillip. "Drug evaluation: ProCord - a potential cell-based therapy for spinal cord injury.." IDrugs : the investigational drugs journal. Vol. 9, no. 5. (January 2006.): -.

Kigerl, K.A., McGaughy, V.M., POPOVICH, P.G. "A comparative analysis of lesion development and inflammation in four strains of mice following spinal contusion injury." J. Comp. Neurol.. Vol. 31(1), (January 2006.): 52-69.

Kigerl, K and POPOVICH, P. "Drug evaluation: ProCord – a potential cell-based therapy for spinal cord injury." IDrugs. Vol. 9(5), (January 2006.): 354-360.

Crutcher, K.A., Gendelmen, H.E., Kipnis, J, Perez-Polo, J.R., Perry, V.H., POPOVICH, P.G., Weaver, L.C. "Debate: Is increasing neuroinflammation beneficial for neural repair.." J. Neuroimmune Pharm.. Vol. 1(3), (January 2006.): 195-211.

Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B. McTigue, D.M., POPOVICH, P.G. "The Basso Mouse Scale for Locomotion (BMS) Detects Differences in Recovery After Spinal Cord Injury in Five Common Mouse Strains.." J. Neurotrauma. Vol. 23(5), (January 2006.): 635-659.

Ankeny, Daniel, P; Lucin, Kurt, M; Sanders, Virginia, M; McGaughy, Violeta, M; Popovich, Phillip G. "Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis.." Journal of neurochemistry. Vol. 99, no. 4. (January 2006.): -.

Ankeny, D.P., Lucin, K.L., Hart, R.P., Sanders, V.M., POPOVICH, P.G. "Spinal cord injury triggers pathological autoantibody synthesis: evidence for systemic and intraspinal B cell activation and differentiation,." J. Neurochemistry. Vol. 99(4), (January 2006.): 1073-87.

Pasterkamp, R Jeroen; Dai, Hai-ning; Terman, Jonathan, R; Wahlin, Karl, J; Kim, Byung; Bregman, Barbara, S; Popovich, Phillip, G; Kolodkin, Alex L. "MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.." Molecular and cellular neurosciences. Vol. 31, no. 1. (January 2006.): -.

Ankeny DP, Popovich PG.. "CNS and non-CNS antigen vaccines exacerbate neuropathology caused by nerve injury.." European Journal of Neuroscience. (January 2007.): -.

Longbrake, Erin, E; Lai, Wenmin; Ankeny, Daniel, P; Popovich, Phillip G. "Characterization and modeling of monocyte-derived macrophages after spinal cord injury.." Journal of Neurochemistry. Vol. 102, no. 4. (January 2007.): -.

Lucin, Kurt, M; Sanders, Virginia, M; Jones, T Bucky; Malarkey, William, B; Popovich, Phillip G. "Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation.." Experimental neurology. Vol. 207, no. 1. (January 2007.): -.

Lucin, K.M., Sanders, V.M., Jones, T.B., Malarkey, W.B., POPOVICH, P.G. ". Impaired systemic immunity after spinal cord injury is level-dependent and results from sympathetic nervous system dysregulation,." In review. (January 2007.): -.

Neigh, G.N., Glasper, E.R., Bowers, S.L., POPOVICH, P.G., DeVries, A.C. "Stress increases anxiety-like behavior and microglial activation following cardiac arrest/cardiopulmonary resuscitation.." In review. (January 2007.): -.

McDaniel, E.E., Lai, W. and POPOVICH, P.G. "In vitro modeling of monocyte-derived macrophage functions for traumatic spinal cord injury.." In review. (January 2007.): -.

Kigerl KA, Rivest S, Hart RP, Satoskar AR, Popovich PG.. "Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury.." Journal of Neurochemistry. (January 2007.): -.

Detloff, M.R., Fisher, L.C., McGaughy, V., McDaniel, E.E., POPOVICH, P.G., Basso, D.M. "Neuropathic pain induced by spinal trauma or nerve ligation activates microglia independent of changes in the p2X4 ATP receptor,." In review. (January 2007.): -.

Holmes, F.E., Arnott, N., Vanderplank, P., Kerr, N.C.H., Longbrake, E., POPOVICH, P.G., Imai, T., Combadiere, C. Murphy, P.M. and Wynick, D. "Fractalkine attenuates neuropathic pain-like behavior via activation of CX3CR1.." In review. (January 2007.): -.

Gray M, Popovich PG, Van Rooijen N, Gupta R.. "Macrophage depletion alters the blood nerve barrier without affecting Schwann cell function after neural injury.." Journal of Neuroscience Research. (January 2007.): -.

Ankeny, D.P. and POPOVICH, P.G. "CNS and non-CNS antigen vaccines exacerbate neuropathology caused by nerve injury,." European J. Neuroscience. (January 2007.): -.

Alexander, J.K., DeVries, A.C. and POPOVICH, P.G. "Stress exacerbates neuropathic pain.." In review. (January 2007.): -.

Popovich, P.G. and Longbrake, E.E.. "Can the immune system be harnessed to repair the CNS?." Nature Rev Neurosci. no. 9. (January 2008.): 481-493.

Holmes, F.E., Arnott, N., Vanderplank, P., Kerr, N.C.H., Longbrake, E., Popovich, P.G., Imai, T., Combadiere, C., Murphy, P.M., and Wynick, D.. "Intra-neural administration of fractalkine attenuates neuropathic pain-related behavior." Journal of Neurochem. Vol. 2, no. 106. (January 2008.): 640-649.

Detloff, M.R., Fisher, L.C., McGaughy, V., McDaniel, E.E., Popovich, P.G., Basso, D.M.. "Remote activation of microglia and proinflammatory cytokines predict the onset and severity of below-level pain after spinal cord injury in rats." Exp Neurology. Vol. 2, no. 212. (January 2008.): 337-347.

Kostyk SK; Popovich PG; Stokes BT; Wei P; Jakeman LB. "Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse.." Neuroscience. Vol. 156, no. 3. (October 2008.): 498-.

Donnelly, D.J. and Popovich, P.G.. "Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury." Exp Neurol. Vol. 2, no. 209. (January 2008.): 378-388.

Kigerl, K.A., Gensel, J.C., Ankeny, D.P., Alexander, J.A. Donnelly, D.J. Popovich, P.G.. "Identification of two distinct macrophage subsets wit hdivergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord." J. Neurosci. (January 2009.): -.

Popovich, P.G, McTigue, D.M.. "Beware the immune system in spinal cord injury." Nature Med. (January 2009.): -.

Donnelly, D.J., Ankeny, D.P. Popovich, P.G.. "Stress exacerbates neuropathic pain via glucocorticoid and NMDA reeptro activation." brain behavior and immunity. (January 2009.): -.

Ankeny, D.P., Guan, Z. Popovich, P.G.. "B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice." J. Clin Invest. (January 2009.): -.

Ankeny DP; Popovich PG. "Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury.." Neuroscience. Vol. 158, no. 3. (February 2009.): 1112-.

Neigh, G.N., Karelina, K., Glasper, E.R., Bowers, S.L., Zhang, N., Popovich, P.G., DeVries. "Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by inocycline." Stroke. (January 2009.): -.

Lucin, K.M., Sanders, V.M. Popovich, P.G.. "Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury." J. Neurochemistry. (January 2009.): -.

Chen, Q., Zhang, H., Li, Q., An, Y., Herkenham, M., Lai, W., Popovich, P., Agarwal, S., Quan, N.,. "Three promotors regulate tissue-and Cell type-specific expressions of murine Il-1R1." J Biol Chem.. (January 2009.): -.

Carsillo, T., Carsillo, M., Traylor, Z., Rajala-Schultz, P., Popovich, P., Niewiesk, S. Oglesbee, M.. "MHC haplotype determines Hsp72-dependent protection against measles virus neurovirulence." J. Virology. (January 2009.): -.

Gensel, J.C., Schonberg, D.L., Alexander, .A., McTigue, D.M Popovich, P.G.. "A semi-automated Sholl analysis technique for quatnifying changes in growth and differentiation of neurons and glia." J Neurosci. Methods. (January 2010.): -.

Naphade, S.B., Kigerl, K.A., Jakeman, L.B., Kostyk, S.K., Popovich, P.G. Kuret, J.. "Proganulin expression is upregulated after spinal contusion in mice." Acta Neuropathol.,. (January 2010.): -.

 

Professional Activities

2009 - present meeting. International Symposium on Neural Regeneration Research. Pacific Grove, CA.
2009 - present 2nd Joint Symposium of the National and International Neurotrauma Societies. Santa Barbara, CA.
2009 - present Society for Neuroscience. Chicago, IL.
2010 - present Canadian SCI Research Symposium.