1900 Coffey Rd
Columbus, OH 43210
Phone: (614) 292-7343
Email: papenfuss.1@osu.edu
Current OSU Appointments
Assistant Professor, Veterinary Biosciences
Assistant Professor, Pulm,Allergy,Crit Care & Sleep
Advising Narrative
I expect that undergraduates will develop sufficient skills and a have a dedicated project that will lead both to the opportunity to present their work and be involved in a publication. The following is a list of the noteworthy accomplishments (e.g. funding, awards and prestigious recognition of their accomplishments) of the undergraduate students that have been or are currently within my lab.
- Julie Baker (B.S. in 12/2012) presented at the Denman Undergraduate Research Forum in 2012 and 2013; received an Honorable Mention 4th place for her Denman 2013 poster, received the 2012 Summer Undergraduate Research Opportunity Program/Mayers Scholarship in Natural and Mathematics Sciences which was provided a summer stipend and was accepted into Medical School at the Ohio University.
- Leanne Diese (B.S. 06/2013) presented at the Denman Undergraduate Research Forum in 2012, was co-author on a publication and was accepted into Veterinary School at the Ohio State University.
Clinical Interest
4,48,53,100
Noteworthy Graduate Narrative
I have M.S., Ph.D. and D.V.M. students which are directly advised by me within my research laboratory. Additionally, I co-advise and provide direct input into the research endeavors of post-doctoral trainees. The following is a list of the noteworthy accomplishments (e.g. funding, awards and prestigious recognition of their accomplishments) of all of these students. (Note: Undergraduate accomplishments are listed elsewhere).
1. M.S. STUDENTS (that have been or are currently in my lab)
- Matthew Sherger (DVM, Oncology Resident, M.S. student in my lab) received a CVM canine grant to support his M.S. work, was 1st author on a manuscript and was invited to present his work at the 2012 Veterinary Cancer Society annual meeting.
- Steven Friedenber (DVM, Emergency, Critical Care Resident, M.S. student in my lab) received a CVM canine grant to support his M.S. work and was invited to present his work at the 2012 Student Veterinary Emergency and Critical Care Annual meeting.
2. Ph.D. STUDENTS (that have been or are currently in my lab)
- Krizia Melendez (B.S., Ph.D. student) received an Excellence Graduate Enrichment Fellowship in 2012 and has present 2 posters within the first 9 months within my laboratory.
- Zachary VanGundy (B.S., Ph.D. student) began as a staff member, started in the M.S. program and has transitioned to the Ph.D. program. During his time in my lab, he has received two invitations to give oral presentations at the 2012 and 2013 American Association of Veterinary Immunologist's meeting, received a 2012 and 2013 travel awards, 2012 Staff Development award, was invited to present his work at the Edward F. Hayes Graduate Reserach Forum (2012 and 2013), was awarded 1st place at the 2013 Russell Klein Nutrition Research Symposium and received 2nd place in the Immunology Round Table Travel Award competition.
3. VETERINARY STUDENTS (that have been or are currently in my lab for summer research projects)
- Dillon Muth: Co-author publication, Recipient of NIH T35 Summer Research Opportunities for Veterinary Students grant, Accepted into Pathology residency/PhD program at Johns Hopkins University
- Ashley Bedarf: Co-author publication
- Jacob Wasserman: 1st author publication, Morris Animal Foundation Veterinary Scholars program recipient
- Amber Singh: Co-author publication, Recipient of NIH T35 Summer Research Opportunities for Veterinary Students grant
- Patricia Gillen: Recipient of NIH T35 Summer Research Opportunities for Veterinary Students grant
- Mary Ormsby: Recipient of NIH T35 Summer Research Opportunities for Veterinary Students grant
4. I have also been involved in the indirect training of POST-DOCS.
- Residents receiving K awards. I assisted 3 post-docs within our residency/PhD programs that received K award training grants from the NIH: Drs. Jessica Grieves, Gillian Beamer and Tracy Carlson.
- Joseph Markowitz (M.D., Ph.D., Post-doc in William Carson's lab) received the 2012 Postdoctoral Pelotonia Fellowship and 2012 OSUCCC Seed Fund award to support his work on regulatory myeloid cells in cancer.
Research Funding
The funding climate is particularly challenging and is unlikely to change in the near future. This, coupled with the increasing interest by funding agencies to support collaborative projects with direct translational applications is the primary reason behind my multi-pronged approach to obtaining funding. Specifically, has provided ample reason for my multi-pronged approach to obtaining sustainable extramural funding.
1. RESEARCH AS A PRINCIPAL INVESTIGATOR: This has been the mainstay of research laboratories for decades. I am committed to obtaining sufficient large extramural grants (e.g. NIH/USDA) to support longer-term projects and Ph.D. graduate students within my lab. As indicated in the Research Focus Narrative, my laboratory has a multi-species, multi-disease approaches.
Continued work on existing grants and funds will be used to generate both publications and preliminary data, both of which are needed to procure R01s. The two primary projects of greatest focus are 1) Develop regulatory myeloid cells for the treatment of inflammatory disease and 2) Understand the role of regulatory myeloid cells in the immunopathogenesis of porcine enteric calicivirus infection. Thus, we will
1) Further develop the data and research objectives from the ongoing R21 and National Blood Foundation Pilot grant, both on Regulatory Myeloid Cells into an R01.
2) Resubmit the scored R01 grant to the NIH/USDA Dual Purpose/Dual Benefit grant opportunity to investigate a pig model for understanding immunpathogenesis of enteric calicivirus infection.
I also have capitalized on smaller grants to support the developing and unique expertise of comparative immunology in my lab and have received Intramural CVM Canine grants and extramural Morris Animal Foundation grants.
2. RESEARCH AS A CO-INVESTIGATOR:
The collaborations that I have with co-investigators build on the various strengths of the different faculty where I provide the myeloid cell/regulatory myeloid cell expertise. This has proven to be a successful strategy given the R21 (Crouser:PI) on Investigating the Effects of Mitochondrial danger signals on Dendritic Cells which is currently being developed into an R01.
I also provide a combination of immunology expertise and pathology expertise (i.e. immunopathology) for larger project grants and, to date, scores/percentiles are very promising for both a P01 (Houghton: PI) and a UH2/UH3 (Schmittgen:PI). I expect to continue such collaborative interactions in a strategic manner that contribute to my research focus on the contribution of regulatory myeloid cells in the immunopathogenesis of disease.
3. ALTERNATIVE AND ADDITIONAL REVENUE STREAMS: Given the ever-challenging funding climate, I am increasingly dialoguing with "non-traditional" grant opportunities. The National Blood Foundation is one such example and numerous grants that I have submitted in the last 7 years have targeted private foundations rather than federal agencies. Also, in the last 12 months, I have started to explore industrial partnerships (e.g. Agenus, Theravasc, Battelle) and will continue to identify non-traditional revenue streams in my developing research areas.
differs significantly than Funding is rey short-term goal is multi-pronged to develop a sustainable extramurally funded lab. Continued work on existing grants and funds will be used to generate both publications and preliminary data, both of which are needed to procure R01s. The two primary projects of greatest focus are 1) Develop regulatory myeloid cells for the treatment of inflammatory disease and 2) Understand the role of regulatory myeloid cells in the immunopathogenesis of porcine enteric calicivirus infection.
Undergraduate, Graduate, and Professional Courses Taught
I provide teaching within my two primary fields of expertise; immunology and veterinary. This is accomplished through either primarily didactic and smaller case-based discussion pedagogical styles depending upon the class, audience and topic.
1. DIDACTIC: My goals within the didactic teaching opportunities (e.g. MVIMG 701, HN8888, VBS 6640, lecture at Ohio Dominican University Physician Assistant students) are to enhance and update the lecture materials with recent research findings and incorporate additional case-based or clinical examples and materials. This is to provide students with current information and relevant real-life applications and these materials will be provided in a lecture-based format with additional audio/visual materials as appropriate. This past year, I developed two new lectures in the topics of 1) Zoonotic diseases to ODU students and 2) Vitamins and hormones: impact on immune response. I also adapted existing lectures for a guest lecture on Tumor immunology and improved my existing lecture on Mucosal Immunology. I will also be preparing an entirely new set of lectures on the topic of Fungal Immunology for the newly developed course MVIMG 801 (Advanced Topics in Immunology).
2. SMALL GROUP DISCUSSION: I am team-leader for the VBS 7717 (elective) course, Veterinary, comparative and translational immunology. Through a combination of small reading assignments with directed questions, I lead the students through discussions on how immunology impacts such topics as global health, cancer, private veterinary practice, zoonotic diseases and others. The class is limited to less than 20 students and consists of 1st and 2nd year veterinary students and graduate students. Students are encouraged (and required) to participate and discuss class topics.
3. CLINICAL INSTRUCTION: Though my clinical service, I provide instruction in the fundamentals of veterinary pathology to VME IV students and 1st year residents during necropsy service and more advanced and individualized instruction to more senior residents during surgical biopsy service. The vast majority of my pathology teaching efforts are individualized and small-group in format which enhances the application of basic principles into a clinical setting. I will continue to develop existing introductory materials and a core set of “lecture” slides to provide basic background information for the 4th year students on this clinical rotations. Ideally, such material could be prepared as an online introduction for students and/or for other students interested in obtaining a basic background on the approach to applied pathology and necropsy clinical case materials.
SUMMARY: Throughout all of my instruction and interactions with individuals throughout the OSU community ( i.e. collaborators and other biomedical researchers) about the contributions and comparative and translational aspect that veterinary medicine and veterinary pathology can bring to a research project and biomedical research endeavor which will benefit both human and animal (OneHealth) medicine.
Chapters in Books
Tracey L. Papenfuss and Caroline C. Whitacre. "Pregnancy, sex hormones and immunity." In Hormones, Brain and Behavior. 2nd ed. Edited by Donald W. Pfaff, et al.. -. Amsterdam ; Boston: Elsevier/Academic Press, January 2009.
Tracey L. Papenfuss. "Monocytes, macrophages and dendritic cells." In Schalms Veterinary Hematology. 6th ed. Edited by Douglass Weiss. -. Oxford: Wiley-Blackwell, January 2010.
Journal Articles
Nout YS, Hinchcliff KW, Bonagura JD, Meurs KM and Papenfuss TL. "Cardiac amyloidosis in a horse." JOURNAL OF VETERINARY INTERNAL MEDICINE. Vol. 17, no. 4. (January 2003.): 588-592.
Powell,Nicole,D; Papenfuss,Tracey,L; McClain,Melanie,A; Gienapp,Ingrid,E; Shawler,Todd,M; Satoskar,Abhay,R; Whitacre,Caroline,C. "Cutting edge: macrophage migration inhibitory factor is necessary for progression of experimental autoimmune encephalomyelitis.." JOURNAL OF IMMUNOLOGY. Vol. 175, no. 9. (November 2005.): 5611-5614.
Rosas,Lucia,E; Snider,Heidi,M; Barbi,Joseph; Satoskar,Anjali,A; Lugo-Villarino,Geanncarlo; Keiser,Tracy; Papenfuss,Tracy; Durbin,Joan,E; Radzioch,Danuta; Glimcher,Laurie,H; Satoskar,Abhay,R. "Cutting edge: STAT1, and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 1. (July 2006.): 22-25.
Mays JW, Bailey MT, Hunzeker JT, Powell ND, Papenfuss T, Karlsson EA, Padgett DA, Sheridan JF. "Influenza virus-specific immunological memory is enhanced by repeated social defeat.." JOURNAL OF IMMUNOLOGY. Vol. 4, no. 184. (February 2010.): 2014-2025.
Kithcart A, Cox G, Sielecki T, Short A, Pruitt J, Papenfuss T, Shawler T, Gienapp I, Satoskar A, Whitacre C. "A Small Molecule Inhibitor of Macrophage Migration Inhibitory Factor for the Treatment of Inflammatory Disease." FASEB JOURNAL. Vol. 24, no. 11. (January 2010.): 4459-4466.
Manickam C, Dwivedi V, Miller J, Papenfuss T, Renukaradhya GJ. "Mycobacterium tuberculosis Whole Cell Lysate Enhances Proliferation of CD8 Positive Lymphocytes and Nitric Oxide Secretion in the Lungs of Live Porcine Respiratory and Reproductive Syndrome Virus Vaccinated Pigs.." VIRAL IMMUNOLOGY. Vol. 26, no. 1. (January 2011.): 102-108.
Park,Jong-Kook; Kogure,Takayuki; Nuovo,Gerard,J; Jiang,Jinmai; He,Lei; Kim,Ji,Hye; Phelps,Mitch,A; Papenfuss,Tracey,L; Croce,Carlo,M; Patel,Tushar; Schmittgen,Thomas,D. "miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival." CANCER RESEARCH. Vol. 71, no. 24. (December 2011.): 7608-7616.
Jaime-Ramirez AC, Mundy-Bosse B, Kondadasula S, Jones NB, Roda JM, Mani A, Parihar R, Karpa V, Papenfuss TL, LaPerle KM, Biller E, Lehman A, Chaudhury AR, Jarjoura D, Burry RW, Carson We 3rd. "Interleukin-12 enhances the anti-tumor actions of trastuzumab via NK cell IFN-gamma production." JOURNAL OF IMMUNOLOGY. Vol. 186, no. 6. (January 2011.): 3401-3409.
Papenfuss TL, Powell ND, McClain MA, Bedarf A, Singh A, Gienapp IE, Shawler T, Whitacre CC. "Estriol generates activated tolerogenic DCs in vivo that protect against autoimmunity." JOURNAL OF IMMUNOLOGY. Vol. 186, no. 6. (January 2011.): 3346-3355.
Wasserman,J; Diese,L; Vangundy,Z; London,C; Carson,W,E; Papenfuss,T,L. "Suppression of canine myeloid cells by soluble factors from cultured canine tumor cells." VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. Vol. 145, no. 1-2. (January 2012.): 420-430.
Julian,Mark,W; Shao,Guohong; Bao,Shengying; Knoell,Daren,L; Papenfuss,Tracey,L; Vangundy,Zachary,C; Crouser,Elliott,D. "Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 1. (July 2012.): 433-443.
Peng,Haiyan; Guerau-de-Arellano,Mireia; Mehta,Veela,B; Yang,Yuhong; Huss,David,J; Papenfuss,Tracey,L; Lovett-Racke,Amy,E; Racke,Michael,K. "Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor kappa B (NF-kappa B) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 287, no. 33. (August 2012.): 28017-28026.
Sherger,Matthew; Kisseberth,William; London,Cheryl; Olivo-Marston,Susan; Papenfuss,Tracey,L. "Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs." BMC VETERINARY RESEARCH. Vol. 8, (October 2012.): 209-.
Manickam,Cordelia; Dwivedi,Varun; Patterson,Ruthi; Papenfuss,Tracey; Renukaradhya,Gourapura,J. "Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs." VETERINARY MICROBIOLOGY. Vol. 162, no. 1. (February 2013.): 68-77.
Reference Works
| January 2002 | Papenfuss TL, Whitacre CC."Increased severity of experimental autoimmune encephalomyelitis (EAE) in male B10.PL mice is accompanied by suppurative meningitis" New Orleans. : abstract #LB445 |
| January 2002 | McClain, M, Papenfuss T, Whitacre C."Effects of Pregnancy on the Disease Course of Experimental Autoimmune Encephalomyelitis (EAE)" . : Part I: A724 |
| January 2003 | McClain MA, Damico N, Papenfuss T, Gienapp I, Song F, Shawler T, Whitacre C.."Pregnancy Suppresses Experimental Autoimmune Encephalomyelitis (EAE) with Increased Immune Reactivity in the Post-partum Period" Denver. : C33 |
| January 2003 | Damico N, Song F, McClain M, Papenfuss T, Gienapp I, Whitacre C.."Differential Activation of Autoreactive T Cells Affects the Induction of Experimental Autoimmune Encephalomyelitis" Denver. : C33 |
| June 2003 | Papenfuss TL, Rogers C, Valo J. Gienapp I, McClain M, Damico N, Whitacre CC."Sex Differences in Experimental Autoimmune Encephalomyelitis (EAE) in Multiple Murine Strains" Denver. : C33 |
| January 2004 | Papenfuss TL, Gienapp IE, Shawler TM, Damico N, McClain MA, Whitacre CC."Alternatively activated macrophages have distinct expression patterns of costimulatory molecules PD-1, PD-L1 and PD-L2" . : Abstract #W11.85 |
| January 2004 | McClain MA, Damico N, Papenfuss TL, Gienapp I, Song F, Shawler T, Whitacre CC."Increased Relapse Severity Occurs Post-partum in Experimental Autoimmune encephalomyelitis (EAE)" . : Part I: A72 |
| January 2004 | Damico N, Satoskar AR, Papenfuss TL, McClain MA, Gienapp IE, Shawler TM Whitacre CC."Macrophage Migration Inhibitory Factor Contributes to Relapses in Experimental Autoimmune Encephalomyelitis (EAE) through Antagonism of Glucocorticoid Production" Montreal. : abstract #W50.107 |
| January 2004 | Whitacre CC, Papenfuss TL, McClain MA, Rogers CL, Damico N, Gienapp IE, Shawler T, Song F."The Influence of Sex and Sex Hormones on the Course of Autoimmune Disease Progression" Montreal. : Abstract #W50.152 |
| January 2005 | Papenfuss TL, Damico N, McClain M, Gienapp IE, Shawler TM, Whitacre CC."Environmental Factors Influence Dendritic Cell Activation and Function: Implications for Experimental Autoimmune Encephalomyelitis (EAE)" Vancouver. |
| January 2005 | Papenfuss TL, Damico N, McClain M, Gienapp I, Shawler T, Song F, Whitacre CC."Differentially matured dendritic cells have divergent immunomodulatory effects on EAE" . : Part I: A327 |
| January 2006 | Papenfuss TL, Powell ND, McClain MA, Gienapp IE, Shawler TM, Whitacre CC."Estriol produces regulatory DCs that influence experimental autoimmune encephalomyelitis" Boston. : S144 |
| June 2006 | Papenfuss TL, Powell N, McClain M, Gienapp I, Shawler T, Whitacre C."Pregnancy hormones produced regulatory DCs that influence the autoimmune disease experimental autoimmune encephalomyelitis" Boston. |
| April 2007 | Papenfuss TL, Kithcart AP, Powell ND, McClain MA, Gienapp IE, Shawler TM, and Whitacre CC."A novel approach to generating disease modifying dendritic cells (DCs)" Miami Beach. : 129.13 |
| June 2007 | Kithcart AP, Powell N, Williams J, Gatson N, Papenfuss T, Gienapp I, Shawler T, Satoskar A, and Whitacre CC."Migration inhibitory factor modulates experimental autoimmune encephalomyelitis through a novel combination of suppressive mediators" Monterey. : 131.34 |
| June 2007 | Gatson NN, Ji H, Gienapp IE, Song F, Papenfuss TL, Camps M, Ruckle T, Zimmerer JL, Shawler TM, Lu B, Gerard C, Kithcart AP, powell N, Fischer AJ, Satoskar A, Whitacre CC."A distinct role for PI3Kgamma in suppressing the development and progression of experimental autoimmune encephalomyelitis (EAE)" Miami Beach. : 129.30 |
| January 2008 | Papenfuss TL, Singh S, Whitacre CC and Boyaka P."Characterization of B16 mFL-expanded DC populations in peripheral and GI lymphoid tissues" San Diego. |
| January 2008 | Papenfuss T, Oglesbee M."An overlooked bottleneck in producing experimental pathologists" San Antonio. |
| June 2008 | Papenfuss TL, Taylor C."Estrogenic microenvironment influences immunity" San Diego. |
| June 2008 | Papenfuss TL, Satoskar A, Lu B, Boyaka, PN."PI3Kgamma regulates mucosal immune responses to epicutaneous immunization with cholera toxin as adjuvant" San Diego. |
| June 2008 | Snider HM, Lockhart G, Barbi J, Papenfuss TL, Lu B, Satoskar AR."The chemokine receptor CXCR3 is required for optimal murine resistance against Toxoplasma gondii" San Diego. |
| June 2009 | • Snider HM, Lockhart G, Barbi J, Papenfuss TL, Lu B, Satoskar AR."The chemokine receptor CXCR3 is required for optimal murine resistance against Toxoplasma gondii" Seattle. |
| September 2009 | Steiner H, Leavell S, Taylor C, Papenfuss T."Four-color analysis of veterinary samples using the Accuri C5 flow cytometer" Columbus. |
| September 2009 | Muth DC, Taylor CL, Bedarf A, Boyaka P, Papenfuss TL."Dendritic cell expansion in vivo and in vitro; developing regulatory dendritic cells" Columbus. |
| December 2009 | Muth DC, Taylor CL, Bedarf A, Boyaka P, Papenfuss TL."Dendritic cell expansion in vivo and in vitro; Developing regulatory dendritic cells" Raleigh-Durham. |
| December 2009 | Muth D, Taylor CL, Bedarf A, Boyaka P, Papenfuss TL."Dendritic cell expansion in vivo and in vitro: Developing Regulatory Dendritic Cells" Monterey. |
| April 2009 | Snider HM, Lockhart G, Barbi J, Papenfuss TL, Lu B, Satoskar AR."The chemokine receptor CXCR3 is required for optimal murine resistance against Toxoplasma gondii" . : 129.30 |
| April 2009 | Papenfuss TL, A Satoskar, B Lu, and PN Boyaka."PI3Kgamma regulates mucosal immune responses to epicutaneous immunization with cholera toxin as adjuvant" . : 39.2 |
| June 2009 | Papenfuss TL and Taylor CL."Estrogenic microenvironment influences immunity" Monterey. : 39.41 |
| June 2010 | Mays J, Bailey MT, Hunzeker JT, Powell ND, Papenfuss TL, Padgett DA, Sheridan JF."Influenza Virus-Specific Immunological Memory Is Enhanced by Repeated Social Defeat" Baltimore. : 2014 |
| September 2010 | Wasserman J, Diese L, VanGundy Z, Singh A, London C, Papenfuss TL."Effects of tumor microenvironment on canine myeloid cell populations. Suppressive Effects of the Tumor Microenvironment on Canine Myeloid Cells" Athens. |
| September 2010 | Singh A, Muth D, Bedarf A, Taylor C, White A, Papenfuss TL."Effects of estriol (E3) on dendritic cells: a potential therapeutic for autoimmune disease" Athens. |
| January 2010 | Manickam C, Dwivedi V, Khatri M, Miller J., Patterson R., Papenfuss T. Gourapura R.."Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge" Chicago. |
| April 2010 | Muth D, Taylor C, Whitacre CC, Boyaka P, Papenfuss T."Developing regulatory dendritic cells with the pregnancy estrogen estriol" . : 98.11 |
| January 2010 | Muth DC, Taylor CL, Bedarf AE, Boyaka PN, TL Papenfuss."Dendritic cell expansion in vivo and in vitro: Developing Regulatory Dendritic Cells" Baltimore. |
| May 2011 | VanGundy Z, Muth DC, White A, Papenfuss TL."Estrogenic microenvironment influences myeloipoiesis to generate regulatory myeloid cells." San Francisco. |
| May 2011 | Baker J, Z VanGundy, D Muth, A White, C Taylor, A Singh, TL Papenfuss."Evaluating the Impact of the Microenvironment in Generating Suppressive Myeloid Cells" Columbus. |
| January 2011 | Wasserman J, Diese L, VanGundy Z, Singh A, London C, Papenfuss TL."Suppressive Effects of the Tumor Microenvironment onCanine Myeloid Cells" Columbus. |
| May 2011 | Wasserman J, Diese L, VanGundy Z, Singh A, London C, Papenfuss TL."Suppressive Effects of the Tumor Microenvironment onCanine Myeloid Cells" Columbus. |
| May 2011 | Diese L, Wasserman J, VanGundy Z, White A, Papenfuss TL."Evaluating the Impact of the Microenvironment in Generating Suppressive Myeloid Cells" Columbus. |
| June 2011 | VanGundy, Z. Taylor, C. White, A. Papenfuss, T."• Tolerogenic DCs differentiation and development of immunosuppressive DC precursors" Boston. |
| May 2012 | Baker J, VanGundy Z, Papenfuss T."Development of metastatic mammary carcinoma model to evaluate myeloid derived suppressor cells and tolergenic dendritic cells" Columbus. |
| June 2012 | VanGundy Z, Muth DC, White A, TL Papenfuss."Microenvironment influences myelopoiesis to generate regulatory myeloid cells" San Francisco. |
| June 2012 | VanGundy Z, Muth DC, White A, Papenfuss TL."Estrogenic microenvironment influences myeloipoiesis to generate regulatory myeloid cells." San Francisco. |
| December 2012 | Gillen P, Wasserman J, Sherger M, Strange H, VanGundy Z, Papenfuss T."In Vitro Production and characterization of canine myeloid derived suppressor cells" Fort Collins. |
| March 2013 | Baker J, VanGundy Z, Strange HR, Papenfuss T."Immunosuppressive Cells in Metastatic Breast Cancer" Columbus. |
| April 2013 | Gillen P, Wasserman J, Sherger M, Strange H, VanGundy Z, Papenfuss T."In Vitro Production and characterization of canine myeloid derived suppressor cells" Columbus. |
| March 2013 | VanGundy ZX, Baker J, Strange H, Papenfuss TL."Differential effects of a metabolite of vitamin A in the development of a regulatory cell" Columbus. |
| March 2013 | VanGundy Z, Baker J, White A, Papenfuss TL."The generation of mature tolerogenic myeloid cells with retinoic acid" Columbus. |
| March 2013 | Baker J, Strange H, Papenfuss TL."Development of a luciferase-transduced metastatic mammary carcinoma tumor model for the in vivo evaluation of the effectiveness of cancer immunotherapies" Columbus. |
| April 2013 | Wasserman J, Papenfuss T."Suppression of canine myeloid cells by soluble factors from cultured canine tumor cells" Columbus. |
| April 2013 | Strange HR, Oglesbee M, Papenfuss TL."Use and application of pigs to investigate the immunopathogenesis of infectious disease" Columbus. |
| April 2013 | Melendez K, Strange H, Papenfuss TL."Development of isolation and evaluation procedures of pig myeloid cells for understanding human disease immunopathogenesis research" Columbus. |
| April 2013 | Melendez K, H Strange, Papenfuss TL."Development of isolation and evaluation procedures of pig myeloid cells for understanding human disease immunopathogenesis research" Columbus. |
| VanGundy ZC, Baker J, Strange H, Papenfuss TL."• Generation of activated regulatory myeloid cells: Differential effects of retinoic acid on myelopoiesis versus dendropoiesis" . | |
| Sherger M, Kisseberth W, London C, Olivo-Marston S, Papenfuss T.."Identification of Myeloid Derived Suppressor Cells in the Peripheral Blood of Tumor Bearing Dogs" . | |
| Papenfuss TL, VanGundy ZC, Sherger M, Wasserman J."Comparative cancer immunology: inducing myeloid suppressor cells in vitro." . | |
| Julian MW, Shao G, VanGundy ZC, Papenfuss TL, Crouser ED."Mitochondrial transcription factor A (TFAM), a danger signal released from damaged cells, promotes an innate immune through RAGE and TLR9 signaling pathways" . |
Presentations
"Selective acute glial necrosis associated with rapid correction of hyponatremia in a dog." Presented at Midwest Association of Veterinary Pathologists, East Lansing, MI. (April 2001)
"Alternatively Activated Macrophages Demonstrate Distinct MHC Class II and Costimulatory Molecule Expression." Presented at Third Annual Post Graduate and Graduate Research Day, . (April 2004)
"Alternatively Activated Macrophages Demonstrate Distinct MHC Class II and Costimulatory Molecule Expression." Presented at College of Veterinary Medicine Research Day, . (January 2004)
"Differentially matured dendritic cells have divergent immunomodulatory effects on EAE." Presented at FASEB, San Diego, CA. (April 2005)
"Environmental Factors Influence Dendritic Cell Activation and Function: Implications for Experimental Autoimmune Encephalomyelitis (EAE)." Presented at Keystone Symposium (B2): Dendritic Cells at the Center of Innate and Adaptive Immunity: Eradication of Pathogens and Cancer and Control of Immunopathology, . (February 2005)
"Sex hormones and autoimmune disease." Presented at Eli Lilly, Indianapolis. (January 2006)
"Estriol Dendritic Cells (DCs) Protect Against Experimental Autoimmune Encephalomyelitis (EAE)." Presented at Advances in Veterinary Medicine Research Day, Columbus, OH. (April 2006)
"Estriol produces regulatory dendritic cells that influence the autoimmune disease EAE." Presented at American Association of Immunologists (AAI), Boston, MA. (May 2006)
"Characterization of B16 mFL-expanded DC populations in peripheral and GI lymphoid tissues." Presented at American Association of Immunologists, . (April 2008)
"An overlooked bottleneck in producing experimental pathologists." Presented at American College of Veterinary Pathologists 59th Annual Meeting, . (January 2008)
"Dendritic cell expansion in vivo and in vitro." Presented at Dendritic cell expansion in vivo and in vitro, Monterey, CA, US|USA. (November 2009)
"PI3Kgamma regulates mucosal immune responses to epicutaneous immunization with cholera toxin as adjuvant." Presented at American Association of Immunologists Annual Meeting, San Diego, CA, US|USA. (April 2009)
"Estrogenic microenvironment influences immunity." Presented at American Association of Immunologists Annual Meeting, San Diego, CA, US|USA. (April 2009)
"Dendritic cell expansion in vivo and in vitro; developing regulatory dendritic cells." Presented at Merck-Merial NIH Veterinary Scholars Symposium, Raleigh-Durham, NC, US|USA. (August 2009)
"Four-color analysis of veterinary samples using the Accuri C6 Flow cytometer." Presented at The Mid Ohio Cytometry Associates Innagural Imaging and Flow Cytometry Research Day, Columbus, OH, US|USA. (September 2009)
"Microenvironmental education of dendritic cells by steroid hormones." Presented at Immunology seminar series, Columbus, OH, US|USA. (April 2010)
"Dendritic cell expansion in vivo and in vitro; developing regulatory dendritic cells." Presented at Summer research retreat and Alumni weekend, Columbus, OH, US|USA. (September 2010)
"Autoimmunity and DC-T cell biology: Introduction to research. Immunology Round Table presentation." Presented at Immunology Round Table, Columbus, OH, US|USA. (January 2010)
"Effects of tumor microenvironment on canine myeloid cell populations. Suppressive Effects of the Tumor Microenvironment on Canine Myeloid Cells." Presented at Merck-Merial Summer Research Program presentation, . (September 2010)
"Effects of estriol (E3) on dendritic cells: a potential therapeutic for autoimmune disease." Presented at Merck-Merial Summer Research Program presentation, . (September 2010)
"Dendritic cells in autoimmunity." Presented at Immunology Round Table, Columbus, OH, US|USA. (March 2010)
"At the Innate-adaptive immune interface: basic science to translational applications." Presented at OSUCCC Innate Immunology seminar, . (March 2010)
"Developing regulatory dendritic cells with the pregnancy estrogen estriol." Presented at Advances in Veterinary Medicine Research Day, Columbus, OH, US|USA. (April 2010)
"Developing regulatory dendritic cells with the pregnancy estrogen estriol." Presented at Advances in Veterinary Medicine Day, Columbus, OH, US|USA. (April 2010)
"Developing regulatory dendritic cells with the pregnancy estrogen estriol." Presented at American Association of Immunologists Annual Meeting, Baltimore, MD, US|USA. (May 2010)
"Suppressive Effects of the Tumor Microenvironment onCanine Myeloid Cells." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2011)
"Suppressive Effects of the Tumor Microenvironment onCanine Myeloid Cells." Presented at OSUCCC 13th Annual Meeting, Columbus, OH, US|USA. (January 2011)
"Evaluating the Impact of the Microenvironment in Generating Suppressive Myeloid Cells." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2011)
"Estrogenic microenvironment influences myeloipoiesis to generate regulatory myeloid cells.." Presented at American Association of Immunologists, San Francisco, CA, US|USA. (May 2011)
Unpublished Works
Pein K, Gupta G, Brackman D, Papenfuss T, Ainslie K, Satoskar A, Bachelder E. Liposomal resiquimod for the treatment of Leishmania donovani infection. February 2013.
Peine KJ, Guerau-de-Arellano M, Lee P, Kanthamneni N, Severin M, Probst GD, Peng H, Yang Y, VanGundy Z, Papenfuss TR, Lovett-Racke AE, Bachelder EM, Ainslie KM. Treatment of experimental autoimmune encephalomyelitis by co-delivery of disease associated peptide and examethasone in acetalated dextran microparticles. April 2013.
VanGundy Z, Baker JD, Taylor CL, White AM, Muth D, Papenfuss TL. Generation of activated regulatory myeloid cells: Differential effects of retinoic acid on myelopoiesis versus dendropoiesis. April 2013.
Powell ND, Papenfuss TL, Sheridan JS. Stress-induced generation, egress, and trafficking of myeloid-derived inflammatory monocytes.
Julian MW, Shao G, VanGundy ZC, Papenfuss TL, Crouser ED. Mitochondrial transcription factor A (TFAM), a danger signal released from damaged cells, promootes and innate immune response through RAGE and TLR9 signaling pathways. February 2012.
Friedenberg S, Strange H, VanGundy Z, Papenfuss TL. The role of mitochondrial DAMPs on the inflammatory response in an in vitro model of canine SIRS.